If you are unable to click Check for updates in Malwarebytes Anti-Malware, then you must run the program as an administrator.
To run Malwarebytes Anti-Malware as an administrator:
For Windows Vista through 10:
- Right-click the icon you use to normally launch Malwarebytes Anti-Malware;
- Click Run as Administrator;
- Click Yes on the prompt.
For Windows XP:
- You will need to log in as an account that has administrator access